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Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. Eur J Haematol Suppl. Mar;(71) doi: /j x. Immune thrombocytopenic purpura: epidemiology and implications for.

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First, it has to be determined that there are no blood abnormalities other than a low platelet count, and no physical signs other than bleeding. The prevalence of Helicobacter pylori infection and the effect of its eradication were monitored in an ITP patient over a period of 12 months.

Tiwaria Manoj Ga Aleem A. A woman with symptomatic thrombocytopenia and an identifiable antiplatelet antibody should be started on therapy for their ITP which may include steroids or IVIG. FDA extends use of Promacta in young children with rare blood disorder. Prevalence of immune thrombocytopenia: Recommendations of the American Society of Hematology. All the petechial lesions were completely resolved over the neck, arm, and forearms.

Management of ITP is based on platelet count and severity of bleeding. ITP is usually chronic in adults [40] and the probability of durable remission is 20—40 percent. Long-term responses seen with rituximab in patients with ITP. By using this site, you agree to the Terms of Use and Privacy Policy. Fetal blood analysis to determine the platelet count is not generally performed as ITP-induced thrombocytopenia in the fetus is generally less severe than NAIT.


The patient was followed-up for 2 years and there was no re-occurence reported. Bleeding time from minor lacerations or abrasions is usually prolonged.

Intraorally there was complete resolution of hematoma anteriorly on gingiva [ Figure 6 ], hematoma in lower anterior lingual region [ Figure 7 ], and petechiae over dorsum of tongue. There is marked variability in the clinical presentation of ITP. Petechial spots on dorsum of tongue, petechial spot on left side hard palate and left maxillary tuberosity region. Two distinct clinical syndromes manifest as an acute condition in children and a chronic condition in adults.

Identifying drugs that cause acute thrombocytopenia: Urea breath testing and stool antigen testing perform better than serology -based tests; moreover, serology may be false-positive after treatment with IVIG. Another option, suitable for Rh-positive patients with functional spleens is intravenous administration of Rho D immune globulin [Human; Anti-D].


Conclusion The initial treatment of ITP includes: No significant difference was noted in the rate of survival between males and females. Randomized trial of anti-D immunoglobulin versus low-dose intravenous immunoglobulin in the treatment of childhood chronic idiopathic thrombocytopenic purpura.

Less common are epistaxis, gingival bleeding, and menorrhagia. In the United States, the adult chronic population is thought to be approximately 60,—with women outnumbering men approximately 2 to 1, which has resulted in ITP being designated an orphan disease. Durable remission following splenectomy is achieved in 75 percent of ITP cases.

ITP may be either acute or chronic.

Chronic Idiopathic Thrombocytopenia Purpura and Helicobacter pylori Eradication: A case study

This observation has led to the development of a class of ITP-targeted medications referred to as thrombopoietin receptor agonists.


Corticosteroids, typically prednisone, are the backbone of the initial treatment. Hypersensitivity and autoimmune diseases Abstract Idiopathic thrombocytopenic purpura ITP is defined as a yrombositopenia disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. It is recommended that pregnant women with thrombocytopenia or a previous diagnosis of ITP should be tested for serum antiplatelet antibodies.

History of presenting illness revealed that patient noticed bleeding from his gums in lower front teeth region approximately 2 weeks before reporting to department and patient was having purpuric pjrpura on body legs, hands, and neck since past 2 months. However, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines [10] and a normal bleeding time does not exclude a platelet disorder.

Adults are usually started on a steroid medicine called prednisone. Support Center Support Center. The patient was prescribed oral wysolone 10mg, once daily initially.

Bleeding time is usually prolonged. Platelet transfusions may be used in severe bleeding together with a very low count.

Immune thrombocytopenic purpura

ITP is a disorder that affects the overall number of blood platelets rather than their function. First, one has to make sure that there are no other blood abnormalities except for low platelet count and no physical signs except for signs of bleeding.

Several studies have proposed that H.