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Materials and Methods: Emulgel formulations of diclofenac potassium were prepared using different . subjected to various evaluation parameters such as drug. Emulgels have been extensively covered as a promising drug delivery system for the administration of lipophilic drugs. This work was. Formulation and Evaluation of Luliconazole Emulgel for. Topical Drug Delivery. Dhobale Shankar,* Shelke Gajanan, Jadhav Suresh, Gaikwad.

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Most remarkable finding was that the anti-inflammatory activity exhibited by aceclofenac microemulsion-based emulgel. Isopropyl myristate showed best solubility amongst all the oils, polysorbate 80 showed two times better solubility than other surfactants and Ethanol showed the 5 times better solubility amongst co-surfactants.

Formulation and evaluation of Cyclosporin A emulgel for ocular delivery.

Elsadig Gasoom FadelAlla Elbashir. In this investigation, a microemulsion-based emulgel of aceclofenac was successfully formulated, which lead to improved solubility and drug release of aceclofenac. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies. These results were concordant with the study conducted by Fathalla et al.

Ethanol was chosen for further studies. Chemate Department Of Pharmaceutics, P. Polysorbate 80, isopropyl myristate, was procured from Molychem Mumbai, India and Loba chemie pvt limited, Mumbai, Indiarespectively. After a number of trials, microemulsion of aceclofenac was optimized with:.

Formulation and evaluation of oxiconazole emulgel for topical drug delivery

A total of 6 rats were used in each group, for formulatino, marketed gel and aceclofenac formulated emulgel, amounting to 18 rats in total. However, side effects such as gastric ulcerogenicity, flatulence, indigestion and nausea, limit the utility of oral aceclofenac 1.

November 12, Journal article Open Access. Anti-inflammatory studies by carrageenan induced paw edema model: The highest drug release was observed with T4, where the drug release showed Thus, the study was conducted to develop novel microemulsion-based emulgel formulations of aceclofenac, a poorly water soluble drug and evaluate its anti-inflammatory activity.

The study yields novel insights into the formulation strategies for designing a water soluble novel drug delivery system of an evapuation, low-solubility drug aceclofenac. The activity produced by the formulated emulgel was at par with the most marketed emulgel formulation.


The findings of the study may yield further avenues for researchers as well as formulation scientists to design further studies on aceclofenac emulgel formulations, using the optimized microemulsion techniques.

The swelling in the paw of each rat was measured by plethysmometer by volume displacement method at baseline and every h till the 6th h In another study by Shah et al. Voltaren emulgel produced maximum inhibition of Additionally, a study conducted by Patel et al. In both the models, animals treated with aceclofenac emulgel showed inflammation reversal in 2 h of application, resulting in improved inhibition of inflammation with an effect lasting up to 6 h.

Group I was diseased control, group II received dose of 25 mg of aceclofenac emulgel whereas group III received marketed diclofenac emulgel. The resulting emulgel was optimized for desired pharmaceutical characteristics and later evaluated for anti-inflammatory effect in rats, comparing against the standard most popular marketed anti-inflammatory emulgel formulation.

The solubilization capability of aceclofenac in different oils, surfactant and co surfactant was shown in the Table 1. All other chemicals and solvents were of analytical reagent grade.

Vol 6 No 3 You can cite all versions by using the DOI The current study focused on the development and optimization of an emulgel formulation of aceclofenac and evaluation of its anti-inflammatory activity fofmulation the standard, most preferred marketed Diclofenac forkulation in experimental animals.

Skin irritation test patch test 7 – The particle size of 1: To overcome this limitation, emulgel, a novel drug delivery has emerged which is a combination of gel and emulsion, adn the presence of gelling agent in the water phase converts a classical emulsion into a gel.

Different formulations F1-F4 of Oxiconazole emulgel was prepared by using carbopol as gelling agent with varying concentrations of oily phase such as liquid paraffin and Tween and Span as a emulsifying agent. Based on the results of this study, pseudo ternary phase diagram was plotted using the Tridraw software, to calculate the surfactant and co-surfactant ratio Smix.


Formulation and Evaluation of Tioconazole Emulgel for Topical Drug Delivery System

Hence, a microemulsion of Aceclofenac was formulated, which was later formed into an emulgel. The emulgsl vivo anti-inflammatory activity of topical aceclofenac emulgel on carrageenan induced paw edema model showed a time dependent response in reduction of inflammation showing the highest inhibition of The micro emulsion rmulgel developed in this maneuver was found to be satisfactory in terms of physical characteristics like clarity, particle size as well and in vitro drug diffusion Fig.

Wistar rats g were divided randomly into three groups. The protocol designed for animal studies was compliant with the CPCSEA guidelines and was approved by the institutional animal ethics committee.

Aceclofenac content in emulgel was measured by dissolving known 0. Hence, the topical route would be one of the ideal alternatives to enhance local delivery, bypassing these side effects. Thus, the microemulsion formulationn aceclofenac emulgel showed promising results as an effective anti-inflammatory topical drug delivery system, in this preliminary investigation.


All the prepared emulgels showed satisfactory physicochemical properties like color, homogeneity, consistency, spreadability, and pH value. Microemulsion-based formulations have lf advantage of improved solubility and have reported to enhance drug permeation, owing to reduced surface tension and particle size 56.

The aliquots 1 mL were collected at time intervals of 1 h up to 8 h. In an earlier study conducted by Pani et al. Thus, the formulated emulgel was considered optimum, based on the pharmaceutical characteristics and further subjected to animal testing for anti-inflammatory activity using two animal models viz.

In this study, polymer-based emulgel formulation of aceclofenac with a microemulsion base was developed and assessed for its anti-inflammatory activity. By the In-vitro diffusion studies it was observed that formulation F1 showed Anbhule Department Of Pharmaceutics, P.