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Hepatocellular carcinoma is a tumor with a high incidence and high mortality. These data .. manejo del CHC celebrada en Barcelona en el an˜o definieron por vez primera .. hepática (clasificación Child-Pugh) y presencia de sıntomas. The present manuscript depicts the Barcelona‐Clínic Liver Cancer Group diagnostic and treatment strategy. This is based on the analysis of. The value of the Barcelona Clinic Liver Cancer and alpha-fetoprotein in the Conclusiones: nuestros resultados confirman que la clasificación BCLC es un.

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Simplified staging for hepatocellular carcinoma. Prognostic prediction and treatment strategy in hepatocellular carcinoma. This classification combines five variables in a score system that stratifies patients in three stages. Prognosis of HCC was assumed to be poor when radical treatments were not feasible.

HCC is now the leading cause of death among cirrhotic patients 3.

Staging systems in hepatocellular carcinoma

Liver cirrhosis was present in Prognostic prediction on HCC: Percutaneous ablation therapies PEI and RF were performed after intravenous analgesia and sedatives, as well as local anesthesia. TNM stage The conventional TNM system, which only contains variables related to tumor stage, has been mostly tested in the surgical setting, and showed poor prognostic prediction in HCC patients undergoing either resection 39 or transplantation The natural course of advanced stage HCC is better known.

Natural history of untreated nonsurgical hepatocellular carcinoma: In Western countries and Japan, hepatitis C virus HCV infection is the main risk factor, together with other causes of cirrhosis 46. Colombo M, Sangiovanni A.


Even some societies have endorsed one of the systems 42with controversial acceptance 43 There are regional variations in the mortality rates of HCC 1,4. Differentiation of early well-differentiated HCC from preneoplastic lesions is a histopathologic challenge, and molecular markers are awaited in this setting 14 Currently, it is de facto reference staging system.

Seminar in Liver Disease ; Prognostic performance of the new classification of primary liver cancer of Japan 4th edition for patients with hepatocellular carcinoma: Prognosis of hepatocellular carcinoma: LlovetSenior Scientist 1 2.

Hepatocellular carcinoma HCC is the most common primary liver malignancy 1 and is the major cause of deaths in patients with cirrhosis 2,3. Accordingly, prognostic modeling in HCC patients is highly complex.

All these factors contribute to difficulty of comparing the different studies. Prognosis of hepatocellular carcinoma: Staging systems in HCC Cancer hepatocadcinoma should serve to select the appropriate primary and adjuvant therapy, to estimate the prognosis, and also to assist in the evaluation of the results of treatment, and to exchange information without ambiguity PEI was performed under ultrasound guidance.

These outcomes are the result of applying the so-called treatment-dependent variables in the selection of candidates. As such, it is necessary to improve the prediction of the barceloha of these patients in order to properly identify the potential candidates for therapy and to critically evaluate the results of new treatment modalities.

Heterogeneity among different studies may reflect both inclusion of patients with different stages of disease and variability in the molecular characteristics and biological behavior of the tumor.

Attempts to improve the classification and prognosis prediction of HCC are still evolving, and there is no agreement on the best staging that can be recommended worldwide Patients with end-stage disease are characterized by presenting Okuda stage III, or Performance Status of 3—4, that reflects a severe tumor-related disability.


A new prognostic classification for predicting survival in patients with hepatocellular carcinoma.

Prognostic factors of hepatocellular carcinoma in patients undergoing hepatic resection. In brief, patients at stage 0 with very early HCC are optimal candidates for resection. A gene-expression signature as a predictor of survival in breast cancer.

The prognostic value of D has not been properly defined. Nowadays, however, the time of diagnosis has been advanced and thus, this classification is not adequate to stratify patients bacrelona to radical or palliative therapies, even when dividing Okuda stage I patients into two subgroups according to tumor size.

Staging systems in hepatocellular carcinoma

First, HCC is a complex neoplasm inserted on a pre-neoplastic cirrhotic liver, and thus variables of both diseases leading to death should be taken into account. Second, the disease is very heterogeneous around the world, and this reflects different underlying epidemiological backgrounds and risk factors.

The figure 3 shows the survival curves according the serum AFP. Patients at stage A with early HCC are candidates for radical therapies resection, liver transplantation or percutaneous treatments. Trends in survival of patients with hepatocellular carcinoma between and in United States