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Ameloblastic fibro-odontoma (AFO) is a benign, slow growing, expansile epithelial odontogenic tumor with odontogenic mesenchyme. Looking for online definition of ameloblastic odontoma in the Medical Dictionary? ameloblastic odontoma explanation free. What is ameloblastic odontoma?. Riddett S.A.A Composite Odontome at a Very Early Age. Brit. Dent. J., 77 (), p. Google Scholar. 2. Kemper J.W., Root to-odontoma. Amer.

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However, malignant transformation into ameloblastic fibrosarcoma was reported by Howell and Burkes.

Contributed by Kelly Magliocca, D. Privacy Policy Terms of Use. Malformed tooth developing in area of prior trauma Could be histologically identical to complex odontoma Osteoma Benign neoplasm composed of mature lamellar bone odkntoma, trabecular or both Can also affect craniofacial bones Should not have odontogenic epithelium Ameloblastic fibro-odontoma AFO Has biphasic mesenchymal and odontogenic epithelium “soft tissue” component that is identical to ameloblastic fibroma Also contains a calcifying component composed of enamel and dentin structures Most recent WHO Odontima of Head and Neck Tumours regards most cases of AFO as developing odontomas rather than a distinct tumor IARC: Oral inspection revealed good oral hygiene.

Many asymptomatic; discovered upon exploring potential causes of Asymmetric tooth eruption Malposition of erupted teeth Occasional devitalization of adjacent teeth Can become symptomatic due to local infection sinusitis, infected adjacent tooth, exposure of odontoma to oral environment, etc and can present with swelling and pain Size: Sign in ajeloblastic customize your interests Sign in to your personal account. The lesions are usually diagnosed during the first and second decades of life [ 4 — 6 ].

International Journal of Dentistry. Most common odontogenic tumor Usually diagnosed during the first two decades of life No sex predilection. An amsloblastic girl presented to our department to have a second opinion regarding a lesion involving her left mandible.


AFO susually affects children or young adults, with no specific sex predilection. In some studies, the term AFO represents a histological combination of ameloblastic amelob,astic and complex odontoma [ 1216 ].

Ameloblastic Fibro-Odontoma: A Diagnostic Challenge

Histopathological study revealed it as an AFO, to our surprise. Orthopantomogram revealsa large, well-defined radiopaque lesion with focal radiolucent areas occupying the whole left body of the mandible.

She had previously undergone several radiographic exams including panoramic, helical, and cone-beam computed tomography. On histopathological examination, it was diagnosed as an AFO. Sign up for our Email Newsletters. View at Google Scholar D. This means that the aforementioned lesions should not be considered as distinct entities [ 11 ]. An analysis of the interrelationship of the mixed odontogenic tumors-ameloblastic fibroma, ameloblastic fibro-odontoma, and the odontomas.

Ameloblastic fibroodontomas AFOs are slow-growing, benign tumors developing from the odontogenic epithelium and ectomesenchyme. The connective tissue is moderately cellular, with spindle-shaped fibroblasts. Odontoameloblastoma, also known as ameloblastic odontoma, has a more aggressive behavior, similar to an ameloblastoma rather than an odontoma [ 9 ]. We planned surgical removal of the tumor along with the impacted third molar under general anesthesia.

Excisional biopsy was performed, and microscopic features showed strands and islands of odontogenic epithelium showing peripheral palisading and loosely arranged central cells, identical to stellate reticulum, embedded in a myxoid cell-rich stroma resembling the dental papilla.

Oral surg Oral Med Oral pathol.

Ameloblastic Odontoma: Report of Two Cases | JAMA Pediatrics | JAMA Network

However, the concept that these lesions represent a continuum of differentiation is not widely accepted, with other researchers suggesting that they are separate pathologic entities [ 12 — 15 ].

While these radiographic examintions were given a presumptive diagnosis of odontoameloblastoma by the examinaing radiologists, we believed that the findings were more common in this region.


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Histopathological study is mandatory in order to differentiate between these two conditions. Postoperative recovery was absolutely uneventful. Dentin and enamel were also present Figure 5.

Our website uses cookies to enhance your experience. Our presumptive diagnosis was complex odontoma.

The clinical examination did not display any sign of pain or swelling in the left mandible. Cahn LR, Blum T.

Ameloblastic fibroodontoma or complex odontoma: Two faces of the same coin

According to the revised World Health Organization WHO classification [ 10 ], ameloblastic fibroma and AFO are believed to be stages of complex odontoma formation [ 1 ].

Treatment included surgical excision of the tumor followed by reconstruction with iliac crest graft. Cahn and Blum [ 13 ] postulated that ameloblastic fibroma the histologically least differentiated tumor develops first into a moderately differentiated form, following AFO and eventually into a complex odontoma. Well defined multiple radiopacities. As noted in the literature, not all lesions previously classified as AFO are, in fact, aggressive lesions.

Radiographically, it appears as a well-circumscribed, expansile radiolucency that generally contains solitary or multiple small radiopaque foci.

ameloblastic odontoma

Conflicts of interest There are no conflicts of interest. Please review our privacy policy. Light microscopic examination of sections stained with hematoxylin and amelloblastic revealed strands and islands of odontogenic epithelium showing peripheral palisading and loosely arranged central cells, identical to stellate reticulum, embedded in a myxoid cell-rich stroma resembling the dental papilla Figure 4.